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Antibiotics and HS: The Double-Edged Sword

The age-old question: if HS isn’t an infection, why are antibiotics part of the treatment plan? It’s a valid concern and one that has sparked heated debates in the HS community and medical professionals alike. Let’s break down why antibiotics are prescribed for HS, how they can help, and the risks involved.


Pills resembling antibiotic medication


Why Are Antibiotics Used for HS?

Antibiotics are traditionally known for fighting infections, but in the case of HS, their role is different. They’re used primarily for their anti-inflammatory and antimicrobial benefits, rather than infection control. While HS itself is not an infectious disease, antibiotics are often a first-line treatment due to their ability to:

  • Reduce inflammation

  • Minimize bacterial presence


However, they are not a cure-all. Antibiotics should never be the sole treatment for HS, whether your condition is mild, moderate, or severe. Their effectiveness often depends on a strategic approach, and overusing them can lead to serious complications.


Misconceptions About Antibiotics and HS

  • HS abscesses are not typically caused by infections. Abscesses can become secondarily infected when bacteria enter through openings, but HS itself is not infectious.

  • Antibiotics are not prescribed to cure HS. Instead, they manage symptoms by addressing inflammation and microbial imbalances.


Why Antibiotics May Seem Effective at First

Some patients experience initial improvement with antibiotics, only to see their symptoms return—sometimes more aggressively. This is often because:

  • Bacteria present initially are eliminated, providing temporary relief.

  • Antibiotics’ anti-inflammatory effects suppress inflammation activity, reducing symptoms in the short term.


This short-term improvement underscores the need for comprehensive treatment plans beyond antibiotics.


The Risks of Long-Term Antibiotic Use

While antibiotics may offer temporary relief, extended use can lead to significant risks, including:

  • Antibiotic Resistance:

    • Resistance occurs when bacteria evolve to withstand antibiotics, rendering them ineffective.

    • It’s the bacteria, not your body, that become resistant.

    • Improper or excessive antibiotic use accelerates this process.

  • Drug-Induced Complications:

    • Some antibiotics, like minocycline, are linked to drug-induced lupus and other immune-related issues.

    • Long-term use may disrupt glucose metabolism, digestion, and immune function.

  • Fungal Overgrowth:

    • By killing beneficial bacteria, antibiotics can promote fungal growth, leading to issues such as yeast infections, jock itch, digestive problems, and even other skin conditions.


Chronic Infections and Antibiotic Use

For some HS sufferers, chronic infections like MRSA (Staph) may develop. These infections, while not necessarily within HS abscesses, require antibiotics to prevent life-threatening complications. In such cases, the benefits of antibiotics outweigh the risks.


Antibiotic Resistance: A Growing Concern

Each time antibiotics are used unnecessarily or improperly, the risk of resistance increases. Resistant bacteria can thrive, making future infections harder to treat. To reduce this risk:

  • Only use antibiotics when prescribed.

  • Avoid overusing antibacterial soaps, particularly those with triclosan.


Fluoroquinolones: Use With Caution

Fluoroquinolone antibiotics, like ciprofloxacin and levofloxacin, should be reserved for cases with no alternatives. The FDA has issued warnings about these drugs due to their potential to cause:

  • Peripheral Neuropathy: Damage to nerves that communicate between the brain and body, causing pain, weakness, and sensory issues.

  • Tendon Injuries: Inflamed or torn tendons, sometimes occurring long after stopping the medication.

  • Other Side Effects: Joint pain, muscle weakness, walking difficulties, and cognitive impairments.


Common Fluoroquinolones Include:

  • Ciprofloxacin (Cipro)

  • Gemifloxacin (Factive)

  • Levofloxacin (Levaquin)

  • Moxifloxacin (Avelox)

  • Norfloxacin (Noroxin)

  • Ofloxacin (Floxin)


A Balanced Approach to Antibiotics

While antibiotics can provide relief, they are not a standalone solution for HS. It’s vital to work with your doctor to develop a comprehensive treatment plan tailored to your needs. This may include:

  • Biologic treatments

  • Lifestyle modifications

  • Other anti-inflammatory medications


Antibiotics are a tool in the HS arsenal, but they must be used wisely. Knowing when they help—and when they harm—is key to managing your condition effectively.

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For more information on the anti-inflammatory and immunomodulatory effects of various antibiotics, visit here.


To learn more about the role of fungus in HS, check out the following articles:


For additional information on antibiotic resistance and side effects, consult resources from:


Read about other treatment options here.



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